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Molecular analysis of ascitic fluid cytology reflects genetic changes of malignancies of the ovary equivalent to surgically resected specimens.

Cancer cytopathology - 1 Aug 2022

Nozaki Takahiro, Sakamoto Ikuko, Kagami Keiko, Amemiya Kenji, Hirotsu Yosuke, Mochizuki Hitoshi, Omata Masao

Abstract excerpt

BACKGROUND: The objective of this study was to identify the clinical utility of genomic analysis of ascitic fluid cytology (AC) in patients with epithelial ovarian cancer. METHODS: Targeted next-generation sequencing was used to analyze 66 samples from 33 patients who had ovarian (n = 23), fallopian tube (n = 2), and peritoneal (n = 8) carcinoma, and the concordance rate of molecular profiles was compared between...

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PMID: 35640087
DOI: 10.1002/cncy.22596

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