Article
Within-host evolution of a Klebsiella pneumoniae clone: selected mutations associated with the alteration of outer membrane protein expression conferred multidrug resistance.
The Journal of antimicrobial chemotherapy - 19 Jan 2021
Aihara Masamune, Nishida Ruriko, Akimoto Masaru, Gotoh Yasuhiro, Kiyosuke Makiko, Uchiumi Takeshi, Nishioka Mitsuaki, Matsushima Yuichi, Hayashi Tetsuya, Kang Dongchon
Abstract excerpt
BACKGROUND: A patient repeatedly developed bacteraemia despite the continuous use of antibiotics. We obtained two Klebsiella pneumoniae isolates from the patient's blood on Days 72 and 105 after hospitalization. Each of the two isolates belonged to ST45, but while the first isolate was susceptible to most antibiotics, the second one was resistant to multiple drugs including carbapenems. OBJECTIVES: To identify...
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