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Fecal Feline Coronavirus RNA Shedding and Spike Gene Mutations in Cats with Feline Infectious Peritonitis Treated with GS-441524.

Viruses - 17 May 2022

Meli Marina L, Spiri Andrea M, Zwicklbauer Katharina, Krentz Daniela, Felten Sandra, Bergmann Michèle, Dorsch Roswitha, Matiasek Kaspar, Alberer Martin, Kolberg Laura, von Both Ulrich, Hartmann Katrin, Hofmann-Lehmann Regina

Abstract excerpt

As previously demonstrated by our research group, the oral multicomponent drug Xraphconn® containing GS-441524 was effective at curing otherwise fatal feline infectious peritonitis (FIP) in 18 feline coronavirus (FCoV)-infected cats. The aims of the current study were to investigate, using samples from the same animals as in the previous study, (1) the effect of treatment on fecal viral RNA shedding; (2) the...

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PMID: 35632813
DOI: 10.3390/v14051069
PMCID: PMC9147249

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