Article
Feline coronavirus with and without spike gene mutations detected by real-time RT-PCRs in cats with feline infectious peritonitis.
Journal of feline medicine and surgery - 1 Aug 2020
Emmler Laura, Felten Sandra, Matiasek Kaspar, Balzer Hans-Joerg, Pantchev Nikola, Leutenegger Christian, Hartmann Katrin
Abstract excerpt
OBJECTIVES: Feline infectious peritonitis (FIP) emerges when feline coronaviruses (FCoVs) mutate within their host to a highly virulent biotype and the immune response is not able to control the infection. FCoV spike (S) gene mutations are considered to contribute to the change in virulence by enabling FCoV infection of and replication in macrophages. This study investigated the presence of FCoV with and without...
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