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Diagnostic Value of Detecting Feline Coronavirus RNA and Spike Gene Mutations in Cerebrospinal Fluid to Confirm Feline Infectious Peritonitis.

Viruses - 27 Jan 2021

Felten Sandra, Matiasek Kaspar, Leutenegger Christian M, Sangl Laura, Herre Stephanie, Dörfelt Stefanie, Fischer Andrea, Hartmann Katrin

Abstract excerpt

BACKGROUND: Cats with neurologic feline infectious peritonitis (FIP) are difficult to diagnose. Aim of this study was to evaluate the diagnostic value of detecting feline coronavirus (FCoV) RNA and spike (S) gene mutations in cerebrospinal fluid (CSF). METHODS: The study included 30 cats with confirmed FIP (six with neurological signs) and 29 control cats (eleven with neurological signs) with other diseases...

Topics

Animals
Case-Control Studies
Cats
Coronavirus, Feline
Feline Infectious Peritonitis
Female
Male
Molecular Diagnostic Techniques
Mutation
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Real-Time Polymerase Chain Reaction

Sensitivity and Specificity

Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 33513683
DOI: 10.3390/v13020186
PMCID: PMC7912268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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