Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors

2 Apr 2019

Abstract excerpt

Viral infections are increasing and probably long-lasting global risks. In this study, a chemical library was exploited by phenotypic screening to discover new antiviral inhibitors. After optimizations from hit to lead, a novel potent small molecule (RYL-634) was identified, showing excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to CRISPR and Genetic Engineering
Share to HIV/AIDS drug development and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30938999
DOI: 10.1021/acs.jmedchem.9b00091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral InhibitorsPMID 30938999Read ↗

A screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compound.Semantic proximity Read ↗

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging VirusesSemantic proximity Read ↗

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2Semantic proximity Read ↗

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2Semantic proximity Read ↗

Discovery of rhodomyrtone as a broad-spectrum antiviral inhibitor with anti-SARS-CoV-2 activitySemantic proximity Read ↗

Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infectionSemantic proximity Read ↗

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3XSemantic proximity Read ↗

Chikungunya virus drug discovery: still a long way to go?Semantic proximity Read ↗

The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus ReplicationSemantic proximity Read ↗

Discovery of an imidazonaphthyridine and a riminophenazine as potent anti-Zika virus agents through a replicon-based high-throughput screeningSemantic proximity Read ↗

Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral AgentsSemantic proximity Read ↗

Broad-Spectrum Antiviral Strategies and Nucleoside AnaloguesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.