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Article

PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2017

Lui Pak-Yin, Wong Lok-Yin Roy, Ho Ting-Hin, Au Shannon Wing Ngor, Chan Chi-Ping, Kok Kin-Hang, Jin Dong-Yan

Abstract excerpt

MDA5 is a RIG-I-like cytoplasmic sensor of dsRNA and certain RNA viruses, such as encephalomyocarditis virus, for the initiation of the IFN signaling cascade in the innate antiviral response. The affinity of MDA5 toward dsRNA is low, and its activity becomes optimal in the presence of unknown cellular coactivators. In this article, we report an essential coactivator function of dsRNA-binding protein PACT in...

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Identifiers

PMID: 28760879
DOI: 10.4049/jimmunol.1601493
PMCID: PMC9202335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization.PMID 28760879Read ↗

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