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The tumour microenvironment as an integrated framework to understand cancer biology

17 Jul 2019

Abstract excerpt

Cancer cells all share the feature of being immersed in a complex environment with altered cell-cell/cell-extracellular element communication, physicochemical information, and tissue functions. The so-called tumour microenvironment (TME) is becoming recognised as a key factor in the genesis, progression and treatment of cancer lesions. Beyond genetic mutations, the existence of a malignant microenvironment forms...

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PMID: 31325528
DOI: 10.1016/j.canlet.2019.07.010

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