Article
Progressing Vulvar Melanoma Caused by Instability in cKIT Juxtamembrane Domain: A Case Report and Review of Literature.
Current oncology (Toronto, Ont.) - 29 Apr 2022
Englert-Golon Monika, Budny Bartłomiej, Lewandowska Małgorzata, Burchardt Bartosz, Smolarek Natalia, Ziemnicka Katarzyna, Jagodziński Paweł Piotr, Ruchała Marek, Grabowska Marlena, Sajdak Stefan
Abstract excerpt
In order to identify the molecular pathways governing melanoma and track its progression, the next-generation sequencing (NGS) approach and targeted sequencing of cancer genes were employed. The primary tumor, as well as metastatic tissue, of an 84-year-old patient diagnosed with vulvar melanoma (VM), were investigated. The primary tumor specimen showed multiple somatic mutations in TP53 gene, suggesting its...
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