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Article

Adipose tissue retains an epigenetic memory of obesity after weight loss

18 Nov 2024

Abstract excerpt

Abstract Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this...

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PMID: 39558077
DOI: 10.1038/s41586-024-08165-7

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