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Article

The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children.

International journal for parasitology. Drugs and drug resistance - 1 Aug 2022

Sugiarto Sri Riyati, Bwire George M, Moore Brioni R, Page-Sharp Madhu, Manning Laurens, Batty Kevin T, Minzi Omary M S, Ngasala Billy, Davis Timothy M E, Makani Julie, Salman Sam

Abstract excerpt

Since there are inconsistent data relating to the effect of haemoglobinopathies on disposition of artemisinin antimalarial combination therapy, and none in sickle cell trait (SCT) or sickle cell disease (SCD), the aim of this study was to characterize the pharmacokinetic properties of artemether-lumefantrine (ARM-LUM) in children with SCD/SCT. Thirty-eight Tanzanian children aged 5-10 years with normal...

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Identifiers

PMID: 35617818
DOI: 10.1016/j.ijpddr.2022.05.002
PMCID: PMC9133758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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