Article
Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria.
Antimicrobial agents and chemotherapy - 1 Aug 2004
Karunajeewa Harin A, Ilett Kenneth F, Dufall Kitiya, Kemiki Adedayo, Bockarie Moses, Alpers Michael P, Barrett P Hugh, Vicini Paolo, Davis Timothy M E
Abstract excerpt
A detailed pharmacokinetic analysis was performed with 47 children from Papua New Guinea with uncomplicated falciparum or vivax malaria treated with artesunate (ARTS) suppositories (Rectocaps) given in two doses of approximately 13 mg/kg of body weight 12 h apart. Following an intensive sampling protocol, samples were assayed for ARTS and its primary active metabolite, dihydroartemisinin (DHA), by liquid...
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