Article

SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART)

2024-08-12

Abstract excerpt

Background Even on the best antimalarial treatments (injectable artesunate) African children with severe malaria have poor outcomes with most deaths occurring early in the course of hospital admission (<24hours). Lactic acidosis, largely due to impairment of the microcirculatory flow due to parasite sequestration, is a main risk factor for poor outcome. There are no adjuvant treatments for severe malaria that targ...

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Literature Corpus work: dbf04f8c-8d93-5875-8468-891b552662a6
DOI: 10.12688/wellcomeopenres.20111.2

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