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Article

AP-1 Subunit JUNB Promotes Invasive Phenotypes in Endometriosis.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Nov 2022

Wilson Mike R, Reske Jake J, Chandler Ronald L

Abstract excerpt

Endometriosis is a disease defined by the presence of abnormal endometrium at ectopic sites, causing pain and infertility in 10% of women. Mutations in the chromatin remodeling protein ARID1A (AT-rich interactive domain-containing protein 1A) have been identified in endometriosis, particularly in the more severe deep infiltrating endometriosis and ovarian endometrioma subtypes. ARID1A has been shown to regulate...

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PMID: 35616875
DOI: 10.1007/s43032-022-00974-3
PMCID: PMC9669088

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Related research

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AP-1 Subunit JUNB Promotes Invasive Phenotypes in Endometriosis.PMID 35616875Read ↗

Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells.Semantic proximity Read ↗

JunB contributes to Id2 repression and the epithelial–mesenchymal transition in response to transforming growth factor–βSemantic proximity Read ↗

Upregulation of SPI1 in Ectopic Endometrium Contributes to an Invasive Phenotype.Semantic proximity Read ↗

Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A/ARID1A axisSemantic proximity Read ↗

ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and Endometriosis-Associated Ovarian CarcinomasSemantic proximity Read ↗

Targeting JUNB to modulate M2 macrophage polarization in preeclampsiaSemantic proximity Read ↗

ARID1A Is Essential for Endometrial Function during Early PregnancySemantic proximity Read ↗

JunB is essential for mammalian placentation.Semantic proximity Read ↗

Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects.Semantic proximity Read ↗

ARID1A maintains transcriptionally repressive H3.3 associated with CHD4-ZMYND8 chromatin interactionsSemantic proximity Read ↗

ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.Semantic proximity Read ↗

Defective endochondral ossification in mice with strongly compromised expression of JunB.Semantic proximity Read ↗

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