Article
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.
Cell reports - 10 Nov 2020
Wilson Mike R, Reske Jake J, Holladay Jeanne, Neupane Subechhya, Ngo Julie, Cuthrell Nina, Wegener Marc, Rhodes Mary, Adams Marie, Sheridan Rachael, Hostetter Galen, Alotaibi Fahad T, Yong Paul J, Anglesio Michael S, Lessey Bruce A, Leach Richard E, Teixeira Jose M, Missmer Stacey A, Fazleabas Asgerally T, Chandler Ronald L
Abstract excerpt
Endometriosis affects 1 in 10 women and is characterized by the presence of abnormal endometrium at ectopic sites. ARID1A mutations are observed in deeply invasive forms of the disease, often correlating with malignancy. To identify epigenetic dependencies driving invasion, we use an unbiased approach to map chromatin state transitions accompanying ARID1A loss in the endometrium. We show that super-enhancers...
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