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Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming

25 May 2022

Abstract excerpt

Using a mouse model, studies by our group reveal that paternal preconception alcohol intake affects offspring fetal-placental growth, with long-lasting consequences on adult metabolism. Here, we tested the hypothesis that chronic preconception male alcohol exposure impacts histone enrichment in sperm and that these changes are associated with altered developmental programming in the placenta. Using chromatin...

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PMID: 35614060
DOI: 10.1038/s41598-022-12188-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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