Article
TIA1 Mutant Mouse Model Exhibits Motor Deficits and Neurodegenerative Characteristics of Amyotrophic Lateral Sclerosis.
Cells - 27 Feb 2026
Mao Li-Hong, Song Yu-Ning, Zhang Jing-Qi, Shao Yun-Ting, Wang Zhang-Li, Yang Na, Zhang Wen-Xuan, Zhang Ying-Rui, Gao Xiao-Yan, Li Jia-Yi, Yuan Lin
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily affects the motor neurons. T cell intracellular antigen 1 (TIA1) is a risk gene for ALS pathogenesis. To elucidate TIA1-mediated disease mechanisms, a mouse model recapitulating clinical and pathological features of ALS is needed. TIA1 mutations are rare in human ALS, and mutations are heterozygous, while...
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