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Low‐density cell culture enhances hepatic function through tight junction formation in HepG2 cells

23 May 2022

Abstract excerpt

BACKGROUND INFORMATION: An in vitro evaluation system using cultured hepatocytes is the most useful method in preclinical research, such as drug metabolism and toxicity test. Human hepatocytes should be used in an in vitro evaluation system because the expression of drug-metabolizing enzymes varies among animal species. HepG2 cells, a liver cancer-derived cell line, are widely used as a human hepatocyte model;...

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PMID: 35603978
DOI: 10.1111/boc.202200002

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