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Article

Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection

15 Jul 2009

Abstract excerpt

BACKGROUND: In order to elucidate how Hepatitis C Virus (HCV) interacts with polarized hepatocytes in vivo and how HCV-induced alterations in cellular function contribute to HCV-associated liver disease, a more physiologically relevant hepatocyte culture model is needed. As such, NASA-engineered three-dimensional (3-D) rotating wall vessel (RWV) bioreactors were used in effort to promote differentiation of...

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PMID: 19604376
DOI: 10.1186/1743-422x-6-103

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