Profound perturbation of the human metabolome by obesity

Abstract excerpt

<h4>ABSTRACT</h4> Obesity is a heterogeneous phenotype that is crudely measured by body mass index (BMI). More precise phenotyping and categorization of risk in large numbers of people with obesity is needed to advance clinical care and drug development. Here, we used non-targeted metabolome analysis and whole genome sequencing to identify metabolic and genetic signatures of obesity. We collected anthropomorphic...

Topics

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• Body Mass Index
• Cross-Sectional Studies
• Diet and metabolism studies
• Epigenetics and DNA Methylation
• Metabolomics and Mass Spectrometry Studies
• Multiomics
• Obesity
• Phenotype

Identifiers and source

Literature Corpus work

60081b15-31fc-5ab6-8f98-d8a8b8dcd34e

DOI

10.1101/298224