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Article

The Landscape of Actionable Gene Fusions in Colorectal Cancer

25 Oct 2019

Abstract excerpt

The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with high microsatellite instability, RAS/BRAF wild-type colorectal cancer. mCRC patients harboring such alterations show...

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PMID: 31731495
DOI: 10.3390/ijms20215319

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