Article
Identification of distinct genomic features reveals frequent somatic AHNAK and PTEN mutations predominantly in primary malignant melanoma presenting in the ureter.
Japanese journal of clinical oncology - 5 Aug 2022
Huang Yan, Wei Lai, Huang Yuanbin, Wen Shuang, Liu Tianqing, Duan Xu, Wang Yutong, Zhang Hongshuo, Fan Bo, Hu Bin
Abstract excerpt
BACKGROUND: Primary malignant melanoma of the ureter is extremely rare. Genetic variants to the increased risk of developing the disease have not yet been investigated. METHODS: Tumour mutation profiling for primary malignant melanoma of the ureter was performed by whole-exome sequencing. Immunohistochemistry was performed to verify histopathological features and the variants of predisposing genes and driver...
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