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Article

Differential expression analysis of genes and long non-coding RNAs associated with KRAS mutation in colorectal cancer cells.

Scientific reports - 13 May 2022

Saliani Mahsa, Jalal Razieh, Javadmanesh Ali

Abstract excerpt

KRAS mutation is responsible for 40-50% of colorectal cancers (CRCs). RNA-seq data and bioinformatics methods were used to analyze the transcriptional profiles of KRAS mutant (mtKRAS) in comparison with the wild-type (wtKRAS) cell lines, followed by in-silico and quantitative real-time PCR (qPCR) validations. Gene set enrichment analysis showed overrepresentation of KRAS signaling as an oncogenic signature in...

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Identifiers

PMID: 35562390
DOI: 10.1038/s41598-022-11697-5
PMCID: PMC9106686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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