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Article

High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.

Molecular medicine (Cambridge, Mass.) - 16 Jun 2021

Tian Chengming, Li Xiyao, Ge Chunlin

Abstract excerpt

BACKGROUND: Pancreatic adenocarcinoma (PAAD) is one of the most challenging cancers with high morbidity and mortality. KRAS mutations could occur as an early event in PAAD. The present study aimed to identify the differentially expressed lncRNAs (DE-lncRNAs) and differentially expressed mRNAs (DE-mRNAs) in KRAS-mutant PAAD to explore the pathogenesis and the underlying molecular mechanism of PAAD development....

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Source

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Identifiers

PMID: 34134622
DOI: 10.1186/s10020-021-00322-2
PMCID: PMC8207728

Genes

KRAS
LAMA3
ATF5
CSHL1
HOXA10
HOXC13
HSF2
NR1I2
SIPA1
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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