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Article

RNA-Based Targeted Gene Sequencing Improves the Diagnostic Yield of Mutant Detection in Chronic Myeloid Leukemia.

The Journal of molecular diagnostics : JMD - 1 Jul 2022

Shanmuganathan Naranie, Wadham Carol, Thomson Daniel, Shahrin Nur Hezrin, Vignaud Chloe, Obourn Vanessa, Chaturvedi Shalini, Yang Feng, Feng Jinghua, Saunders Verity, Kok Chung H, Yeung David, King Rob M, Kenyon Rosalie R, Lin Ming, Wang Paul, Scott Hamish, Hughes Timothy, Schreiber Andreas W, Branford Susan

Abstract excerpt

Mutation detection is increasingly used for the management of hematological malignancies. Prior whole transcriptome and whole exome sequencing studies using total RNA and DNA identified diverse mutation types in cancer-related genes associated with treatment failure in patients with chronic myeloid leukemia. Variants included single-nucleotide variants and small insertions/deletions, plus fusion transcripts and...

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PMID: 35550185
DOI: 10.1016/j.jmoldx.2022.04.004

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