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Article

Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2022

Nassan Malik, Daghlas Iyas, Winkelman John W, Dashti Hassan S, Saxena Richa

Abstract excerpt

Insomnia and restless leg syndrome (RLS) are associated with increased risk for suicidal behavior (SB), which is often comorbid with mood or thought disorders; however, it is unclear whether these relationships are causal. We performed a two-sample Mendelian randomization study using summary-level genetic associations with insomnia symptoms and RLS against the outcomes of risk of major depressive disorder (MDD),...

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Share to Depressive Disorder, Major
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Sleep Initiation and Maintenance Disorders

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Source

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Identifiers

PMID: 35538198
DOI: 10.1038/s41386-022-01319-z
PMCID: PMC9283512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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