Article
Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank.
BMC medicine - 3 Apr 2023
Gibson Mark J, Lawlor Deborah A, Millard Louise A C
Abstract excerpt
BACKGROUND: Insomnia symptoms are widespread in the population and might have effects on many chronic conditions and their risk factors but previous research has focused on select hypothesised associations/effects rather than taking a systematic hypothesis-free approach across many health outcomes. METHODS: We performed a Mendelian randomisation (MR) phenome-wide association study (PheWAS) in 336,975 unrelated...
Topics
- Humans
- Sleep Initiation and Maintenance Disorders
- Biological Specimen Banks
- Genome-Wide Association Study
- Phenotype
- United Kingdom
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide