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Article

Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits.

Sleep - 11 Aug 2022

Lasconi Chiara, Pahl Matthew C, Pippin James A, Su Chun, Johnson Matthew E, Chesi Alessandra, Boehm Keith, Manduchi Elisabetta, Ou Kristy, Golson Maria L, Wells Andrew D, Kaestner Klaus H, Grant Struan F A

Abstract excerpt

We investigated the potential role of sleep-trait associated genetic loci in conferring a degree of their effect via pancreatic α- and β-cells, given that both sleep disturbances and metabolic disorders, including type 2 diabetes and obesity, involve polygenic contributions and complex interactions. We determined genetic commonalities between sleep and metabolic disorders, conducting linkage disequilibrium...

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Identifiers

PMID: 35537191
DOI: 10.1093/sleep/zsac109
PMCID: PMC9366645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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