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Common variants of RARRES2 and RETN contribute to susceptibility to hand osteoarthritis and related pain.

Biomarkers in medicine - 1 Jun 2022

Yan Shaoyao, Liu Hongliang, Nie Huiyong, Bu Gang, Yuan Weili, Wang Suoliang

Abstract excerpt

Aim: To examine the relationship of the RETN and RARRES2 genes with hand osteoarthritis (HOA) susceptibility risk, clinical severity and pain. Methods: A total of 3740 subjects comprising 1180 participants with HOA and 2560 controls were enrolled. Genetic association was evaluated at both single marker and haplotype levels using PLINK. Results: Two significant hits, single-nucleotide polymorphism (SNP) rs4721...

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PMID: 35531645
DOI: 10.2217/bmm-2022-0103

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