Article
An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs.
BMC bioinformatics - 8 May 2022
Fauman Eric B, Hyde Craig
Abstract excerpt
BACKGROUND: A genome-wide association study (GWAS) correlates variation in the genotype with variation in the phenotype across a cohort, but the causal gene mediating that impact is often unclear. When the phenotype is protein abundance, a reasonable hypothesis is that the gene encoding that protein is the causal gene. However, as variants impacting protein levels can occur thousands or even millions of base...
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