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Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia

24 Aug 2021

Abstract excerpt

BACKGROUND: Non-obstructive azoospermia (NOA) is the most severe form of male infertility; more than half of the NOA patients are idiopathic. Although many NOA risk genes have been detected, the genetic factors for NOA in majority of the patients are unknown. In addition, it is difficult to retrieve sperm from these patients despite using the microsurgical testicular sperm extraction (microTESE) method....

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PMID: 34429122
DOI: 10.1186/s12958-021-00815-z

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Related research

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Research trail→

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Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermiaPMID 34429122Read ↗

Novel Variants in HFM1 Lead to Male Infertility Due to Non-obstructive AzoospermiaSemantic proximity Read ↗

A novel splicing mutation in helicase for meiosis 1 leads to non-obstructive azoospermia.Semantic proximity Read ↗

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Genetic and functional analysis reveals novel mutations in meiotic genes underlying non-obstructive azoospermia.Semantic proximity Read ↗

BiallelicHFM1variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degreesSemantic proximity Read ↗

Identification of deleterious variants in patients with male infertility due to idiopathic non-obstructive azoospermiaSemantic proximity Read ↗

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