Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients.

doi:10.1158/2159-8290.CD-21-1434

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Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients.

Cancer discovery - 6 Jul 2022

Crisafulli Giovanni, Sartore-Bianchi Andrea, Lazzari Luca, Pietrantonio Filippo, Amatu Alessio, Macagno Marco, Barault Ludovic, Cassingena Andrea, Bartolini Alice, Luraghi Paolo, Mauri Gianluca, Battuello Paolo, Personeni Nicola, Zampino Maria Giulia, Pessei Valeria, Vitiello Pietro Paolo, Tosi Federica, Idotta Laura, Morano Federica, Valtorta Emanuele, Bonoldi Emanuela, Germano Giovanni, Di Nicolantonio Federica, Marsoni Silvia, Siena Salvatore, Bardelli Alberto

Abstract excerpt

The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond to immune-checkpoint blockade. We previously reported that the treatment of colorectal cancer preclinical models with temozolomide (TMZ) leads to MMR deficiency, increased tumor mutational burden (TMB), and sensitization to immunotherapy. To...

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PMID: 35522273
DOI: 10.1158/2159-8290.CD-21-1434
PMCID: PMC9394384

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