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Article

Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells.

Cancer science - 1 Jan 2021

Sakakitani Shintaro, Podyma-Inoue Katarzyna A, Takayama Rina, Takahashi Kazuki, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Harada Hiroyuki, Watabe Tetsuro

Abstract excerpt

Metastasis is a primary reason related to the mortality of oral squamous cell carcinoma (OSCC) patients. A program called epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. During EMT, epithelial cancer cells acquire motile mesenchymal phenotypes and detach from primary tumors. Recent lines of evidence have suggested that EMT...

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Identifiers

PMID: 33007125
DOI: 10.1111/cas.14670
PMCID: PMC7780019

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