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Article

Haplotype phasing of a bipolar disorder pedigree revealed rare multiple mutations of SPOCD1 gene in the 1p36-35 susceptibility locus.

Journal of affective disorders - 1 Aug 2022

Takamatsu Gakuya, Yanagi Kumiko, Koganebuchi Kae, Yoshida Fuyuko, Lee Jun-Seok, Toyama Kanako, Hattori Kotaro, Katagiri Chiaki, Kondo Tsuyoshi, Kunugi Hiroshi, Kimura Ryosuke, Kaname Tadashi, Matsushita Masayuki

Abstract excerpt

BACKGROUND: The etiology of bipolar disorder (BD) is poorly understood. Considering the complexity of BD, pedigree-based sequencing studies focusing on haplotypes at specific loci may be practical to discover high-impact risk variants. This study comprehensively examined the haplotype sequence at 1p36-35 BD and recurrent depressive disorder (RDD) susceptibility loci. METHODS: We surveyed BD families in Okinawa,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35504398
DOI: 10.1016/j.jad.2022.04.150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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