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Article

DNA repair and damage pathways in mesothelioma development and therapy

2 May 2022

Abstract excerpt

Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis. Other important etiologies for MMe development include DNA damage, over-activation of survival signaling pathways, and failure of DNA damage response (DDR). In this review article, first, we will describe the most important signaling...

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PMID: 35501851
DOI: 10.1186/s12935-022-02597-9

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