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Article

Is DNA repair a potential target for effective therapies against malignant mesothelioma?

Cancer treatment reviews - 1 Nov 2020

Fuso Nerini Ilaria, Roca Elisa, Mannarino Laura, Grosso Federica, Frapolli Roberta, D'Incalci Maurizio

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a rare malignancy mainly caused by asbestos exposure. Germinal and acquired mutations in genes of DNA repair pathways, in particular of homologous recombination repair, are frequent in MPM. Here we overview the available experimental data suggesting that an impaired DNA repair system affects MPM pathogenesis by leaving lesions through the genome unresolved. DNA repair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32892058
DOI: 10.1016/j.ctrv.2020.102101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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