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Article

Statistical parametrization of cell cytoskeleton reveals lung cancer cytoskeletal phenotype with partial EMT signature.

Communications biology - 2 May 2022

Basu Arkaprabha, Paul Manash K, Alioscha-Perez Mitchel, Grosberg Anna, Sahli Hichem, Dubinett Steven M, Weiss Shimon

Abstract excerpt

Epithelial-mesenchymal Transition (EMT) is a multi-step process that involves cytoskeletal rearrangement. Here, developing and using an image quantification tool, Statistical Parametrization of Cell Cytoskeleton (SPOCC), we have identified an intermediate EMT state with a specific cytoskeletal signature. We have been able to partition EMT into two steps: (1) initial formation of transverse arcs and dorsal stress...

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Identifiers

PMID: 35501466
DOI: 10.1038/s42003-022-03358-0
PMCID: PMC9061773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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