Article
Novel insights into the genetic profile of hereditary spastic paraplegia in India.
Journal of neurogenetics - 1 Mar 2022
Narendiran Sundarapandian, Debnath Monojit, Shivaram Sumanth, Kannan Ramakrishnan, Sharma Shivani, Christopher Rita, Seshagiri Doniparthi V, Jain Sanjeev, Purushottam Meera, Mangalore Sandhya, Bharath Rose Dawn, Bindu Parayil Sankaran, Sinha Sanjib, Taly Arun B, Nagappa Madhu
Abstract excerpt
The Hereditary Spastic Paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by length dependent degeneration of the corticospinal tracts. Genetic data related to HSPs are limited from India. We aimed to comprehensively analyse the phenotypic characteristics and genetic basis of a large cohort of HSP from India. Patients with HSP phenotype were evaluated for their...
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