Article

Genetic Landscape of Hereditary Spastic Paraplegia in Iran: Insights from Novel variants and Genotype-Phenotype Correlations

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> Background Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by progressive lower limb spasticity and muscle weakness. Despite increasing genetic insights worldwide, the mutational landscape and genotype-phenotype correlations of HSP remain unclear in the Iranian population. This study aims to provide...

Identifiers and source

Literature Corpus work: e4c9a24e-72c4-5892-b5fa-6b2f0eac42c9
DOI: 10.21203/rs.3.rs-10615106/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Genetic Landscape of Hereditary Spastic Paraplegia in Iran: Insights from Novel variants and Genotype-Phenotype CorrelationsDOI 10.21203/rs.3.rs-10615106/v1Read

Expanding the genetic and clinical landscapes of hereditary spastic paraplegia (HSP): a cohort study of 103 families.Semantic proximity Read

Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional StudySemantic proximity Read

New genetic causes for complex hereditary spastic paraplegia.Semantic proximity Read

Genetic landscape of hereditary spastic paraplegias in the Korean population.Semantic proximity Read

The Investigation of Genetic and Clinical Features in Patients with Hereditary Spastic Paraplegia in Central-Southern ChinaSemantic proximity Read

Hereditary spastic paraplegia type 11: Clinicogenetic lessons from 339 patients.Semantic proximity Read

The emerging genetic diversity of hereditary spastic paraplegia in Korean patients.Semantic proximity Read

Review of the Genetic Spectrum of Hereditary Spastic Paraplegias in the Middle East and North Africa RegionsSemantic proximity Read

Hereditary spastic paraplegia: new insights into clinical variability and spasticity-ataxia phenotype, and novel mutations.Semantic proximity Read

Description of clinical features and genetic analysis of one ultra-rare (SPG64) and two common forms (SPG5A and SPG15) of hereditary spastic paraplegia families.Semantic proximity Read

Clinical and genetic study of hereditary spastic paraplegia in CanadaSemantic proximity Read

Diagnostic Yield and Genotype-Phenotype Correlations of Clinical Exome Sequencing in Hereditary Spastic Paraparesis: Experience From Eastern Spain.Semantic proximity Read