Article
Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2023
Ramos Jairo, Caywood Laura J, Prough Michael B, Clouse Jason E, Herington Sharlene D, Slifer Susan H, Fuzzell M Denise, Fuzzell Sarada L, Hochstetler Sherri D, Miskimen Kristy L, Main Leighanne R, Osterman Michael D, Zaman Andrew F, Whitehead Patrice L, Adams Larry D, Laux Renee A, Song Yeunjoo E, Foroud Tatiana M, Mayeux Richard P, St George-Hyslop Peter, Ogrocki Paula K, Lerner Alan J, Vance Jeffery M, Cuccaro Michael L, Haines Jonathan L, Pericak-Vance Margaret A, Scott William K
Abstract excerpt
INTRODUCTION: Studies of cognitive impairment (CI) in Amish communities have identified sibships containing CI and cognitively unimpaired (CU) individuals. We hypothesize that CU individuals may carry protective alleles delaying age at onset (AAO) of CI. METHODS: A total of 1522 individuals screened for CI were genotyped. The outcome studied was AAO for CI individuals or age at last normal exam for CU...
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