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Whole-genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese.

Genomics, proteomics & bioinformatics - 28 Oct 2025

Wang Mengying, Sun Liyang, Xu Xin, Dai Ruoqi, Tan Qilong, Zhu Yun, Xu Andi, Zheng Weifang, Tu Yuanxing, Zhou Dan, Li Wenyuan, Wu Xifeng

Abstract excerpt

Subjective cognitive decline (SCD) is widely regarded as a potential preclinical stage of Alzheimer's disease (AD), yet its genetic basis remains poorly understood. To address this gap, we investigated genetic biomarkers associated with SCD using whole-genome sequencing (WGS) in 10,763 Chinese participants from the Healthy Zhejiang One Million People Cohort (HOPE Cohort). The discovery stage included 9284...

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Source

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Identifiers

PMID: 40728933
DOI: 10.1093/gpbjnl/qzaf063
PMCID: PMC12561000

Genes

SCD
SEPHS2
CLVS2

Provenance

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