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Article

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes.

Nature genetics - 1 Nov 2021

Mansour Aly Dina, Dwivedi Om Prakash, Prasad Rashmi B, Käräjämäki Annemari, Hjort Rebecka, Thangam Manonanthini, Åkerlund Mikael, Mahajan Anubha, Udler Miriam S, Florez Jose C, McCarthy Mark I, Brosnan Julia, Melander Olle, Carlsson Sofia, Hansson Ola, Tuomi Tiinamaija, Groop Leif, Ahlqvist Emma

Abstract excerpt

Type 2 diabetes has been reproducibly clustered into five subtypes with different disease progression and risk of complications; however, etiological differences are unknown. We used genome-wide association and genetic risk score (GRS) analysis to compare the underlying genetic drivers. Individuals from the Swedish ANDIS (All New Diabetics In Scania) study were compared to individuals without diabetes; the...

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PMID: 34737425
DOI: 10.1038/s41588-021-00948-2

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