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Article

Utility of germline multi-gene panel testing in patients with endometrial cancer.

Gynecologic oncology - 1 Jun 2022

Karpel Hannah C, Chern Jing-Yi, Smith J Maria, Smith A Julia, Pothuri Bhavana

Abstract excerpt

OBJECTIVES: Patients with germline mutations in mismatch repair genes (MLH1, MSH2, MSH6, PMS2) associated with Lynch syndrome (LS) have an increased lifetime risk of endometrial cancer (EC). Multi-gene panel testing (MGPT) is a recent hereditary cancer risk tool enabling next-generation sequencing of numerous genes in parallel. We determined the prevalence of actionable cancer predisposition gene mutations...

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Identifiers

PMID: 35483985
DOI: 10.1016/j.ygyno.2022.04.003

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