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Article

Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2016

Ring Kari L, Bruegl Amanda S, Allen Brian A, Elkin Eric P, Singh Nanda, Hartman Anne-Renee, Daniels Molly S, Broaddus Russell R

Abstract excerpt

Hereditary endometrial carcinoma is associated with germline mutations in Lynch syndrome genes. The role of other cancer predisposition genes is unclear. We aimed to determine the prevalence of cancer predisposition gene mutations in an unselected endometrial carcinoma patient cohort. Mutations in 25 genes were identified using a next-generation sequencing-based panel applied in 381 endometrial carcinoma patients...

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Source

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Identifiers

PMID: 27443514
DOI: 10.1038/modpathol.2016.135
PMCID: PMC5541389

Genes

BRCA2
BRIP1
MSH2
MSH6
PMS2
APC
ATM
BARD1
BRCA1
CHEK2
EPCAM
MLH1
NBN
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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