Article
duper is a null mutation of Cryptochrome 1 in Syrian hamsters.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2022
Lee Yin Yeng, Cal-Kayitmazbatir Sibel, Francey Lauren J, Bahiru Michael Seifu, Hayer Katharina E, Wu Gang, Zeller Molly J, Roberts Robyn, Speers James, Koshalek Justin, Berres Mark E, Bittman Eric L, Hogenesch John B
Abstract excerpt
The duper mutation is a recessive mutation that shortens the period length of the circadian rhythm in Syrian hamsters. These animals show a large phase shift when responding to light pulses. Limited genetic resources for the Syrian hamster (Mesocricetus auratus) presented a major obstacle to cloning duper. This caused the duper mutation to remain unknown for over a decade. In this study, we did a de novo genome...
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