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Article

TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux

23 Feb 2024

Abstract excerpt

Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB), remain a global threat exacerbated by increasing drug resistance. Host-directed therapy (HDT) is a promising strategy for infection treatment through targeting host immunity. However, the limited understanding of the function and regulatory mechanism of host factors involved in immune defense against infections has impeded HDT...

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PMID: 38390831
DOI: 10.1080/15548627.2024.2321831

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