Article
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains.
Oncogene - 15 Jan 2015
Ren T, Takahashi Y, Liu X, Loughran T P, Sun S-C, Wang H-G, Cheng H
Abstract excerpt
The retroviral oncoprotein Tax from human T-cell leukemia virus type 1 (HTLV-1), an etiological factor that causes adult T-cell leukemia and lymphoma, has a crucial role in initiating T-lymphocyte transformation by inducing oncogenic signaling activation. We here report that Tax is a determining factor for dysregulation of autophagy in HTLV-1-transformed T cells and Tax-immortalized CD4 memory T cells. Tax...
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