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Article

Differential VHL Mutation Patterns in Bilateral Clear Cell RCC Distinguishes Between Independent Primary Tumors and Contralateral Metastatic Disease.

Urology - 1 Jul 2022

Vocke Cathy D, Ricketts Christopher J, Metwalli Adam R, Pinto Peter A, Gautam Rabindra, Raffeld Mark, Merino Maria J, Ball Mark W, Linehan W Marston

Abstract excerpt

OBJECTIVE: To evaluate whether bilateral, multifocal clear cell renal cell carcinoma (ccRCC) patients can be differentiated by VHL mutation analysis into cases that represent either multiple independently arising primary tumors, or a single primary tumor which has spread ipsilaterally as well as to the contralateral kidney. The nature of kidney cancer multifocality outside of known hereditary syndromes is as yet...

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Identifiers

PMID: 35469800
DOI: 10.1016/j.urology.2022.04.003
PMCID: PMC9296614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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