Article
Genetic identification of bilateral primary or metastatic nonpapillary renal cell carcinoma.
BJU international - 1 Aug 2000
Kume H, Oda H, Nakatsuru Y, Shimizu Y, Takahashi Y, Matsumoto T, Inoue T, Kameyama S, Kitamura T, Ishikawa T
Abstract excerpt
OBJECTIVE: To clarify the clonality of bilateral tumours by genetic analysis of bilateral renal cell carcinomas (RCCs) using the VHL gene, which is inactivated in approximately 60% of RCCs and which plays a causal role in the development of most cases of nonpapillary RCC. PATIENTS AND METHODS: The study included 20 patients; seven had von Hippel-Lindau disease, three had papillary RCC and 10 had nonpapillary RCC....
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