Article
"Association of MTHFR and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case-control study encompassing meta-analysis and trial sequential analysis".
BMC pediatrics - 25 Apr 2022
Raina Jyotdeep Kour, Panjaliya Rakesh Kumar, Dogra Vikas, Sharma Sushil, Anupriya, Kumar Parvinder
Abstract excerpt
BACKGROUND: The risk of Congenital Heart Defects (CHD) is greatly influenced by variants within the genes involved in folate-homocysteine metabolism. Polymorphism in MTHFR (C677T and G1793A) and MS/MTR (A2756G) genes increases the risk of developing CHD risk, but results are controversial. Therefore, we conducted a case-control association pilot study followed by an up-dated meta-analysis with trial sequential...
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